Yes! Cyrillic has a "Multiple document interface". This means that you can have several files open at once, allowing you to compare families and copy information between them.

Cyrillic 2 can import the following data file types:

• Standard Cyrillic format
• Pedigree/Draw Macintosh
• LinkSys Import/Export
• Both varieties of MLINK pedigree files
• CriMap format
• An extended GEDCOM format

See Questions 13 and 14 for further information.

Cyrillic is designed for Microsoft Windows. However, if your Macintosh has a DOS card or SoftWindows (A Windows emulation application) you will be able to run Cyrillic.

The toolbar for Cyrillic 2 was designed to be used with a SuperVGA display. When it is run on a VGA display, some of the buttons are not displayed because of the limited display area. If you are unable to use SVGA mode, choose these commands from the Edit menu.

Please ensure you are using the latest release version of Cyrillic.  Free patches are available for versions 2.0.x and 2.1.x.  If these don't help then please contact us at support@cyrillicsoftware.com with full details of your problem.

We are grateful to Alejandro Schaffer for allowing us to distribute a version of FASTLINK suitable for use with Cyrillic's example files, such as the Breast Cancer example.

Download for Windows 95/98/NT

Download for Windows 3.1

The source code for these and other  programs (for example, Cri-Map, LINKAGE) are available from Web Resources for Genetic Linkage Analysis , courtesy of the Laboratory of Statistical Genetics at Rockefeller University. There are also links from here to other web and ftp sites around the world.

If you run the downloaded file by double-clicking it you will be prompted to extract the files to either C:\FL4WIN32 (when running FL4WIN32.EXE) or C:\FL3WIN16 (when running FL3WIN16).  It is recommended that you accept this default directory.

To perform a linkage analysis:

Run Cyrillic and open your family file, ensuring that the data directory has been correctly set.

• Choose File|Export->MLINK, select the markers to analyze and then navigate to e.g. C:\LINKAGE.

  Note, the Export File Location dialog also has check boxes to Run MLINK, Rewrite the locus file, and View the results (OUTFILE.DAT).

• Follow through the remaining prompts, setting values as are appropriate to your analysis.
• The analysis will proceed -- a DOS Window appears showing the progress of the analysis. A successful run is usually accompanied by a long scrolling list of results in this window.
• If prompted, close the DOS window and the results will be displayed in NOTEPAD. You can view the results at a later date in e.g. C:\LINKAGE\OUTFILE.DAT

To perform a Breast Cancer analysis:

Run Cyrillic using the "Breast Cancer Example" icon and open your family file, or the example file BRCA.FAM

Choose "Data|Run BrCa- Breast Cancer Susceptibility"

The analysis will now run to completion without any further prompting.  See the Breast Cancer Module page.

Choose File|Print Options|Setup|Options and then change the Scaling of the output, say, to 125 percent.

Use the Print Preview Option. In this mode, you can increase or decrease the size of the family in relation to the original using the percentage zoom drop-down list, in the toolbar as well as other useful features such as scale to fit and the ability to position the pedigree over a number of pages.

You can also make symbols larger without rescaling the drawing by modifying the Symbol Width attribute under the Display Format menu.

If you delete parents, Cyrillic will be unable to establish that the siblings are related. You can hide individuals, rather than delete them in order to maintain relationships between individuals. You can either hide partners from the display (See Options menu) or, in the Print Options dialog box you can choose Ignore Nameless Persons whenever you are printing a list.

No. However, because you control what information is shown on the pedigree, you do not need to display the date on-screen (See Format|Display Format).

The GEDCOM standard release v5.5 manual can be viewed online. The current official GEDCOM documents are available at at ftp.gedcom.org .

The easiest way to import information from a database into Cyrillic 2 is to export your data as an ASCII file (Plain text file) with the information arranged within that file in one of the formats supported by Cyrillic 2. You will need to set up a "macro" or "export filter" that will allow you to automate the procedure of automatically formatting the ASCII output from your database into one of the eight popular genetic file formats supported by Cyrillic 2. However, you will need to investigate yourself as to how to set up such macros/filters - please refer to the documentation that comes with your database program.

You will need to manipulate your ASCII files to match the GEDCOM format if you want rich and extensive data transfer. However, if you just need basic patient information and marker details then we advise following the Standard Cyrillic format.

Another option would be to export a plain ASCII file from your database, open it in a text editor (such as Word, or Windows Notepad) and manually change the format to match that of your chosen import format although this can sometimes be rather time-consuming.

You can find more information about this whole topic beginning on page 120 of the Cyrillic 2.0 manual - all of the import formats are also described in detail in this particular section.

Technical Support Pages